Exocrine Pancreatic Insufficiency

In late 2021/early 2022, I realized I have moderate exocrine pancreatic insufficiency (EPI). There’s not a lot of information written and targeted at patients, and there’s also gaps in the medical literature and research studies regarding optimal titration of enzymes (known as Pancreatic Enzyme Replacement Therapy, or PERT). I spent some time figuring out how to optimally dose and titrate PERT and other enzyme sources, essentially developing a method for creating a lipase:fat and protease:protein ratio for better dosing enzymes (and building an iOS app called “PERT Pilot” to help other people do the same).

These are some of the posts that I’ve written about EPI (also known as PEI) that might be of use to anyone else with EPI.

You can help us learn more about exocrine pancreatic insufficiency. Take the anonymous survey about EPI symptoms: https://bit.ly/GI-Symptom-Survey-All


A gif showing a square moving along a spectrum from "too little" to "too much enzyme". Too little enzyme and you have symptoms, not enough and you reduce but don't eliminate symptoms. Enough enzymes and you eliminate symptoms. Too much risks constipation.